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Given the above evidence, the use of CE for the clinical management of various diseases is expected to increase. Previous experimental studies have found that CE showed several pharmacological activities, including antioxidant, antifungal, antibacterial, hepato-protective, anticonvulsant, cytotoxic, and sedative-hypnotic properties (Mehrabani et al., 2007 ▶ Ganapaty et al., 2013 ▶ Jafarian et al., 2014 ▶ Sudam et al., 2017 ▶ Chabra et al., 2019 ▶ Forouzanfar et al., 2020 ▶). According to the results of an ethnobotanical study conducted in Iran, CE (in Persian: Aftimun) was reported as one of the top-selling products in traditional herbal medicine markets (Amiri and Joharchi, 2013 ▶). Traditionally, CE has been used for the treatment of insanity (Iran), diabetes (Morocco), burn injuries (India), psychometric disorders (India), liver disorders (India), vision improvement (Greece), and rheumatism (China) (Kong and Chen, 1996 ▶ Jouad et al., 2001 ▶ Rout et al., 2013 ▶ Sharma et al., 2014 ▶ Shah et al., 2015 ▶). CE has several secondary metabolites such as saponins, glycosides, tannins, steroids, kaempferol, and quercetin (Chabra et al., 2019 ▶). It has slender stems with small leaves appearing in different colors like yellow, red, purple, and pink (Costea and Tardif, 2006 ▶). Cuscuta epithymum (dodder) is a parasitic and not photosynthetically active plant assigned to the Convolvulaceae family. Nevertheless, several experimental studies and clinical reports have found that medicinal plants might potentially have side effects like synthetic drugs (Farzaei et al., 2020 ▶).
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This assumption may lead to their indiscriminate use. Medicinal plants are generally considered safe due to their natural origin and cultural acceptability. Nowadays, the usage of medicinal plants is increasing around the world (Caporale et al., 2020 ▶).